E-400 Drug Information [ Douglas Laboratories ]

Table of content

E-400 category:

• Human
• Vitamin Supplements
• Vitamin E

Active ingredients:

• Vitamin E (D-Alpha Tocopherol Acid Succinate)

E-400 companies and manufacturers:

• Douglas Laboratories

General Information

E-400 forms, composition and dosages:

• Capsule; Oral; Vitamin E (D-Alpha Tocopherol Acid Succinate) 400 units

Indications, usages and classification codes:

• A11HA03 - Tocopherol (Vitamin E)

There is an additional general information about this medication active ingredient vitamin e (tocopherol acetate, tocopherol palmitate or other related chemical compounds):

Pharmacological action

Tocopherol (vitamin e) has an antioxidant effect, is involved in the biosynthesis of heme and proteins, cell proliferation, tissue respiration, and other critical processes of tissue metabolism, prevents hemolysis of red blood cells, prevents increased permeability and capillary fragility. This medication fills a shortage of vitamin E. Inhibits free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes. Stimulates the synthesis of heme and heme containing enzymes - hemoglobin, myoglobin, cytochromes, catalase and peroxidase. Improves tissue respiration, stimulates the synthesis of proteins (collagen, enzymes, structural and contractile proteins of skeletal and smooth muscle, the myocardium), protects against oxidation of vitamin A. Inhibits the oxidation of unsaturated fatty acids and selenium (a component of microsomal electron transport system). Inhibits the synthesis of cholesterol. From the gastrointestinal tract is slowly absorbed about 50%, the highest level in the blood after 4 hours for absorption requires bile acids. In the process of absorption forms a complex with lipoproteins, which are intracellular carriers of vitamin E. Comes mainly in the lymph, then - in the general circulation, where it binds primarily to alpha-1 and beta-lipoprotein, in part - to serum albumin. When metabolic protein transport is difficult. Deposited in the adrenal glands, pituitary, testes, fat and muscle tissue, erythrocytes and liver. Undergoes metabolism and is excreted from the body (in unmodified form and as metabolites) in bile (90%) and urine (about 6%).

Pharmacokinetics

If ingestion absorption of 50% during suction forms a complex with lipoproteins (intracellular carriers of tocopherol). For absorption requires bile acids. Associated with alpha1- and beta-lipoprotein, in part - to serum albumin. When metabolic disorders a protein transport is difficult. C_max is reached after 4 h. Deposited in the adrenal glands, pituitary, testes, fat and muscle tissue, erythrocytes and liver. More than 90% is excreted in bile, 6% - the kidneys.

Why is E-400 by Douglas Laboratories prescribed?

Vitamin deficiencies, conditions of convalescence after a disease occurring with a feverish syndrome, high physical activity, older age, disease ligamentous system and muscles. Climacteric autonomic disorders. Neurasthenia with fatigue, asthenia neurasthenic syndrome, primary muscular dystrophy, posttraumatic, postinfectious secondary myopathy. Degenerative and proliferative changes in the joints and ligamentous apparatus spine and large joints.

Dosage and administration

Usually prescribed to 100-300 mg / day. If necessary the dose may be increased to 1 g / day.

E-400 by Douglas Laboratories side effects

Possible: an allergic reaction, with a reception in high doses - diarrhea, epigastric pain, when IM injection - pain, infiltration at the injection site.

Contraindications

Increased sensitivity to tocopherol.

Using during pregnancy and breastfeeding

Tocopherol is used during pregnancy and lactation (breastfeeding) when indicated.

Special instructions

With caution tocopherol should be used in severe cardiosclerosis, myocardial infarction, with an increased risk of venous thromboembolism.

E-400 by Douglas Laboratories drug interactions

In an application with tocopherol may change the effects of warfarin and dicoumarol.
There are reports of reduced effectiveness of simultaneous treatment with iron for children.
With the simultaneous application of tocopherol with cyclosporine increased absorption of cyclosporine.

E-400 by Douglas Laboratories in case of emergency / overdose

Symptoms: creatinuria, diarrhea, epigastric pain, decreased capacity for work.

• E-400 analogs
• E-400 similar